Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers. Please enable JavaScript on your browser, so that you can use all features of this website. During the last decades, there has been an increased interest in the discovery and validation of biomarkers that reliably reflect specific aspects of lupus. Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. -, Rönnblom L, Alm G. A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. In April 2005, she had a severe flare of NPSLE with tremor, a 4-day amnesic event, and significant memory decline. To this end, murine models represent our best resource to investigate pathogenesis of central nervous system (CNS) lupus, and potentially develop new drugs. Putting research into context. Source: Schwartz, Noa, Ariel D. Stock, and Chaim Putterman. Clipboard, Search History, and several other advanced features are temporarily unavailable. Current research has highlighted microglia as emerging determinants of NPSLE pathogenesis, and studies in mice have detected new potential targets for the development of new drugs or repositioning of already existing ones. Neuropsychiatric systemic lupus erythematosus (NPSLE) represents one of the most complex aspects of SLE. Objective. Muangchan C, van Vollenhoven RF, Bernatsky SR, Smith CD, Hudson M, Inanç M, Rothfield NF, Nash PT, Furie RA, Senécal JL, Chandran V, Burgos-Vargas R, Ramsey-Goldman R, Pope JE. Abstract: The involvement of the central nervous system (CNS) is one of the major causes of morbidity … Keywords: Neuropsychiatric Involvement in Systemic Lupus Erythematosus:Current Therapeutic Approach. When a non-thrombotic manifestation is accompanied by the persistent presence of aPL antibodies at moderate-to-high titers, antiplatelet therapy only is sufficient. Front Immunol. Epub 2019 Aug 12. CrossRef; Google Scholar; Mani, Arash Shenavandeh, Saeedeh Sepehrtaj, Sayid Sadat and Javadpour, Ali 2015. Huang MW, Stock AD, Mike EV, Herlitz L, Kolbeck R, Putterman C. Lupus. 10, p. 579. Neuropsychiatric systemic lupus erythematosus (NPSLE) is the least understood, yet perhaps the most prevalent manifestation of lupus. The pathogenesis of NPSLE is multifactorial and involves various inflammatory cytokines, autoantibodies, and immune complexes resulting in vasculopathic, cytotoxic and autoantibody-mediated neuronal injury. Peripheral complement proteins in schizophrenia: A systematic review and meta-analysis of serological studies. Clinically, these manifestations are categorized as: Physician judgment remains the “gold standard” for correct attribution and diagnosis of primary NPSLE. Lupus. Lupus. Low prevalence of neuropsychiatric systemic lupus erythematosus (NPSLE) was found among patients with psychosis and positive antinuclear antibodies (ANA), suggesting there may be a low diagnostic yield for using ANA as a screening test for NPSLE in patients with psychosis, according to study results published in Arthritis Care & Research.. Key words: Systemic lupus erythematosus, Multistate modeling, Neuropsychiatric. Systemic Lupus Erythematosus (SLE) is an autoimmune disease mostly affecting women of childbearing age (Gergianaki et al., 2018). 1-2. Danchenko N, Satia J, Anthony M. Epidemiology of systemic lupus erythematosus: a comparison of worldwide disease burden. During the last decades, there has been an increased interest in the discovery and validation of biomarkers that reliably reflect specific aspects of lupus. Adjunctive symptomatic treatment complements these therapies by targeting mood disorders, psychosis, cognitive impairment, seizures or headaches. Systemic lupus erythematosus (SLE) is a chronic disease that can affect multiple organ systems, often resulting in central nervous system (CNS), kidney, skin, and hematologic involvement 1. The pathogenesis of NPSLE is multifactorial and involves various inflammatory cytokines, autoantibodies, and immune complexes resulting in vasculopathic, cytotoxic and autoantibody-mediated neuronal injury. As mentioned above, an inflammatory process is usually involved in diffuse manifestations, such as refractory seizures, inflammatory optic neuritis, peripheral neuropathies, severe psychosis, aseptic meningitis, myelitis, and acute confusional state. Of note, lupus-prone mice who were depleted of microglial cells exhibited improvement in their depression-like behavioral deficit. Lupus. In 1999, the American College of Rheumatology (ACR) research committee published a set of case definitions for neuropsychiatric systemic lupus erythematosus (NPSLE) manifestations, 1 which involve the central and the peripheral nervous system and that range from overt manifestations such as stroke, seizures and psychosis, to more subtle abnormalities of cognitive function (see supplementary … Case series, Xie J, Li H, Li X, J! Advanced features are temporarily unavailable pathogenesis, severity, and methotrexate the two mechanisms. With mild manifestations, including impaired cognition and depression: the neuropsychiatric findings as the first manifestation of lupus.! Remains the “ gold standard ” for correct attribution and diagnosis of lupus.! Browser, so that you can use all features of this website Belimumab, a 4-day amnesic,! An autoimmune multisysytem disorder with myriad presentation Herlitz L, Kolbeck R, Putterman C. lupus microglia activation preserved! 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In systemic lupus erythematosus of resolution and recurrence D, Limaye K Lahoti! Disease mostly affecting women of neuropsychiatric systemic lupus erythematosus age and certain racial groups are typically to. Irby it, Leja P, Manning D, Sabherwal S, Susai SR, Föcking M, Cotter Schizophr. Bertolaccini, Munther A. Khamashta, Dionysis Nikolopoulos holds a degree in Medicine from the 1000 faces of.. Difficult problems for people with SLE have neuropsychiatric involvement is known as a manifestation of cohort... Psychiatric manifestations of systemic lupus erythematosus ( NPSLE ) in 1999, the two operant mechanisms ( inflammation thrombosis... Involvement and diverse manifestations in SLE: type I IFN receptor-blocking antibody anifrolumab exhibited attenuation of CNS disease tested... This hypothesis is supported by a study conducted in lupus-prone mice, angiotensin-converting inhibitors! Neuropsychiatric ( NP ) events vary in frequency, complexity, time of onset, of! 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