In a single-center analysis of 118 infants undergoing craniosynostosis repair (ESC 80 cases versus open 38 cases), the authors reported no coagulation product administration in the ESC group and 18% for open reconstruction procedures. Surgical intervention during infancy for both syndromic and nonsyndromic patients with craniosynostosis remains the criterion standard of treatment with the 2 main options being open vault remodeling versus minimally invasive surgery. Meticulous hemostasis and early transfusion can mitigate the results of blood loss. Introduction. Conclusions : Craniosynostosis surgery is safe with low rates of mortality and acute complications. Bleeding is the main cause of mortality after surgery to correct craniosynostosis. Although open cranial vault remodeling was initially considered a high-risk procedure, many advances have improved its safety. Mortality rate was <1%. Most cases of craniosynostosis are compatible with survival, although a high mortality rate is observed during the neonatal period in some conditions [5,6]. LOS >4.2 appears to be associated more with comorbidities than with complications. Increasing length of surgery was also associated with the need for an intraoperative transfusion. We conducted a retrospective 30-year review of craniosynostosis surgery at a single major craniofacial institute to establish the rate and predictors of complications. The high failure rate and mortality burden in these early cases had two possible antecedents: 1) microcephaly was misdiagnosed as craniosynostosis or 2) the surgery was performed late; they were possibly less associated with a high surgical risk itself. Sagittal Craniosynostosis – the sagittal suture is the most commonly affected suture at approximately 60%. Mortality rate: 19% Complications: bile leakage, deep vein thrombosis, and infection U.S. doctors perform over 500,000 gallbladder removals each year. LOS >4.2 appears to be associated more with comorbidities than with complications. Higher rates of comorbidities and LOS >4.2 days for patients age 1 to 3 years warrant addition research to assess potential barriers to care. Conclusions. The incidence of Craniosynostosis is approximately 1 in 2000/3000 births…. Craniosynostosis, the premature fusion of cranial sutures, occurs in approximately 3.5–4.5 out of 10,000 live births worldwide (Cohen and MacLean, 2000).Although Samuel Thomas von Soemmerring first realized the association between premature cranial suture fusion and dysmorphic cranial growth in 1791, Virchow is credited with coining the term craniosynostosis and … CVR procedures to correct craniosynostosis are known to result in extensive blood loss. This 20-year experience demonstrates the safety of modern open craniosynostosis repairs at a large academic medical center with low rates of mortality (0%), complications (1.2%), and reoperations (2.5%). [23, 24] Craniosynostosis surgery is safe with low rates of mortality and acute complications. While death from the routine surgery … 1. Multidisciplinary care involving plastic surgery and neurosurgery is generally accepted as optimal to manage craniosynostosis to avoid complications and to identify patients at risk. Careful planning of the delivery method and perinatal care is crucial because of the potential for complex anomalies of the … in other words, there is approximately 175 infants born each day with Craniosynostosis. The mean length of surgery in the transfusion group was 3.62 (range, 1.2–6.33; SD, 1.16) versus 2.12 hours (range, 1.47–3.27; SD, 0.65) in the no-transfusion group with a P value <0.001. 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